Enzyme Stabilization

CD Biosynsis is a leading AI enzyme expert with extensive experience in using artificial intelligence to promote enzyme discovery and design. With our advanced computer algorithms, our enzyme experts use single or combinatorial protein engineering strategies to design and optimize enzymes with high stability for you, thus adapting to the needs of different application industries.

Overview of Enzyme Stabilization

Enzymes are protein molecules consisting of folded polypeptide chains of amino acids that are essential to perform an array of biological functions. Due to enzymes being capable of high selectivity, They catalyze reactions and are therefore very useful in many industrial and pharmaceutical fields. Enzyme stability refers to the ability of enzymes to maintain certain spatial structures. Two main types of stability can be defined: one is the stability of an enzyme when stored in a dehydrated preparation, solution, or immobilized form, specifically regarding the retention of activity over time. Another is the retention of enzyme activity during use. In order to extend their service life, certain means need to be used to improve their stability, including protein or media engineering and chemical modification. Typically, strategies to improve enzyme stability and delay enzyme denaturation require balancing three competing interests: (i) maintaining high enzyme activity, 2) ensuring good long-term performance against temperature, dehydration, organic solvents, and/or aggressive pH stability, and 3) achieving regulation or reversible conversion of enzyme activity.

Category: General