Small Genome Synthesis

Small Genome Synthesis (SGS) refers to the process of constructing a smaller genome through synthetic methods. It is an artificial synthetic biology technique aimed at assembling genomes into smaller artificial chromosomes or synthetic genomes for genetic engineering or synthetic biology research.

SGS technology typically involves breaking down DNA sequences into smaller fragments and then combining these fragments together using chemical synthesis methods. These fragments can come from natural genome pruning or synthetic gene fragments designed by computers. With the increase and connection of synthetic fragments, the target genome can ultimately be constructed.

The synthesis of small genomes provides many advantages. Firstly, by constructing smaller genomes, scientists can conduct functional and evolutionary research on microorganisms, understanding how key parts of the genome interact with each other. Secondly, synthetic microgenomes can be used to design and construct specialized microorganisms to produce useful compounds such as drugs and biofuels. In addition, SGS can provide an effective method for genome editing and recombination.

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Category: General