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 Anonymous February 23, 2024 |
Discovery of NeoantigensNeoantigens are newly formed antigens produced by tumor cells due to various tumor-specific alterations, such as genomic mutations, RNA splicing dysregulation, post-translational modification disturbances, and integrated viral open reading frames. With the development of next-generation sequencing and bioinformatics technology, the rapid identification and prediction of tumor-specific neoantigens becomes possible. Compared with tumor-associated antigens, highly immunogenic and tumor-specific neoantigens provide new targets for personalized immunotherapy of tumors and can be used as prospective predictors of tumor survival prognosis and response to immune checkpoint blockade index. Learn more?discovery of neoantigens Category: General |
